Vetispiradienska sintaza
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| Vetispiradienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.21 | ||||||||
| CAS broj | 192465-18-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Vetispiradienska sintaza (EC 4.2.3.21, farnezil pirofosfatna ciklaza (formira vetispiradien), pemnaspirodienska sintaza, HVS, vetispiradienska ciklaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira vetispiradien).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat vetispiradien + difosfat
Inicijalna interna ciklizacija proizvodi monociklični intermedijer germakren A.
Reference[uredi | uredi kod]
- ↑ Back, K. and Chappell, J. (1995). „Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases”. J. Biol. Chem. 270: 7375-7381. PMID 7706281.
- ↑ Keller, H., Czernic, P., Ponchet, M., Ducrot, P.H., Back, K., Chappell, J., Ricci, P. and Marco, Y. (1998). „Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco”. Planta 205: 467-476.
- ↑ Mathis, J.R., Back, K., Starks, C., Noel, J., Poulter, C.D. and Chappell, J. (1997). „Pre-steady-state study of recombinant sesquiterpene cyclases”. Biochemistry 36: 8340-8348. PMID 9204881.
- ↑ Yoshioka, H., Yamada, N. and Doke, N. (1999). „cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans”. Plant Cell Physiol. 40: 993-998. PMID 10588069.
- ↑ Martin, V.J., Yoshikuni, Y. and Keasling, J.D. (2001). „The in vivo synthesis of plant sesquiterpenes by Escherichia coli”. Biotechnol. Bioeng. 75: 497-503. PMID 11745124.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.