Veoma-dugačak-lanac (3R)-3-hidroksiacil-(acil-nosilac protein) dehidrataza
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| Veoma-dugačak-lanac (3R)-3-hidroksiacil-(acil-nosilac protein) dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.134 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Veoma-dugačak-lanac (3R)-3-hidroksiacil-(acil-nosilac protein) dehidrataza (EC 4.2.1.134, PHS1 (gen), PAS2 (gen)) je enzim sa sistematskim imenom veoma-dugačak-lanac (3R)-3-hidroksiacil-(acil-nosilac protein) hidrolijaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- veoma-dugačak-lanac (3R)-3-hidroksiacil-[acil-nosilac protein] veoma-dugačak-lanac trans-2,3-dehidroacil-[acil-nosilac protein] + H2O
Ovaj enzim je komponenta elongaze, mikrozomalnog proteinskog kompleksa odgovornog za produžavanje palmitoil-KoA i stearoil-KoA do acil KoA veoma dugačkog lanca.
Reference[uredi | uredi kod]
- ↑ Bach, L., Michaelson, L.V., Haslam, R., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J.P., Miquel, M., Tellier, F., Domergue, F., Markham, J.E., Beaudoin, F., Napier, J.A. and Faure, J.D. (2008). „The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development”. Proc. Natl. Acad. Sci. USA 105: 14727-14731. PMID 18799749.
- ↑ Kihara, A., Sakuraba, H., Ikeda, M., Denpoh, A. and Igarashi, Y. (2008). „Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation”. J. Biol. Chem. 283: 11199-11209. PMID 18272525.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.