Ubikvitin-proteinska ligaza
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| Ubikvitin-proteinska ligaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 6.3.2.19 | ||||||||
| CAS broj | 74812-49-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ubikvitin-proteinska ligaza (EC 6.3.2.19, ubikvitin-aktivirajući enzim) je enzim sa sistematskim imenom ubikvitin:protein-lizin N-ligaza (formira AMP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ubikvitin je vezan za ovaj protein peptidnom vezom između C-terminalnog glicina ubikvitina i epsilon-amino grupa lizinskih ostataka proteina.
Reference[uredi | uredi kod]
- ↑ Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982). „Covalent affinity purification of ubiquitin-activating enzyme”. J. Biol. Chem. 257: 2537-2542. PMID 6277904.
- ↑ Haas, A.L. and Rose, I.A. (1982). „The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis”. J. Biol. Chem. 257: 10329-10337. PMID 6286650.
- ↑ Haas, A.L., Warms, J.V.B., Hershko, A. and Rose, I.A. (1982). „Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation”. J. Biol. Chem. 257: 2543-2548. PMID 6277905.
- ↑ Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986). „The protein substrate binding site of the ubiquitin-protein ligase system”. J. Biol. Chem. 261: 11992-11999. PMID 3017957.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.