Ubikvitin-kalmodulinska ligaza
(Preusmjereno sa stranice Ubikvitin-kalmodulin ligaza)
| Ubikvitin-kalmodulinska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.21 | ||||||||
| CAS broj | 119632-60-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ubikvitin-kalmodulinska ligaza (EC 6.3.2.21, ubikvitil-kalmodulinska sintaza, ubikvitin-kalmodulinska sintetaza, ubikvitil-kalmodulinska sintetaza, uCaM-sintetaza) je enzim sa sistematskim imenom kalmodulin:ubikvitin ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- n ATP + kalmodulin + n ubikvitin n AMP + n difosfat + (ubikvitin)N-kalmodulin
Ovaj enzim je specifičan za Ca2+-kalmodulin kod kičmenjaka.
Reference[uredi | uredi kod]
- ↑ Jennissen, H.P. and Laub, M. (1988). „Ubiquitin-calmodulin conjugating activity from cardiac muscle”. Biol. Chem. Hoppe-Seyler 369: 1325-1330. PMID 2853950.
- ↑ Ziegenhagen, R. and Jennissen, H.P. (1988). „Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase”. Biol. Chem. Hoppe-Seyler 369: 1317-1324. PMID 2853949.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.