UDP-N-acetilglukozaminska 2-epimeraza (hidroliza)
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| UDP-N-acetilglukozaminska 2-epimeraza (hidroliza) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.183 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
UDP-N-acetilglukozaminska 2-epimeraza (hidroliza) (EC 3.2.1.183, GNE (gen), siaA (gen), neuC (gen)) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin hidrolaza (2-epimerizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-glukozamin + H2O N-acetil-D-manozamin + UDP
Enzim je izdvojen iz jetre sisara, kao i iz nekih patogenih bakterija uključujući Neisseria meningitidis i Staphylococcus aureus.
Reference[uredi | uredi kod]
- ↑ Stasche, R., Hinderlich, S., Weise, C., Effertz, K., Lucka, L., Moormann, P. and Reutter, W. (1997). „A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase”. J. Biol. Chem. 272: 24319-24324. PMID 9305888.
- ↑ Chou, W.K., Hinderlich, S., Reutter, W. and Tanner, M.E. (2003). „Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-N-acetylglucosamine 2-epimerase”. J. Am. Chem. Soc. 125: 2455-2461. PMID 12603133.
- ↑ Blume, A., Ghaderi, D., Liebich, V., Hinderlich, S., Donner, P., Reutter, W. and Lucka, L. (2004). „UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells”. Protein Expr. Purif. 35: 387-396. PMID 15135418.
- ↑ Murkin, A.S., Chou, W.K., Wakarchuk, W.W. and Tanner, M.E. (2004). „Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase”. Biochemistry 43: 14290-14298. PMID 15518580.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.