UDP-N-acetilglukozamin—undekaprenil-fosfat N-acetilglukozaminfosfotransferaza
| UDP-N-acetilglukozamin—undekaprenil-fosfat N-acetilglukozaminfosfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.33 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
UDP-N-acetilglukozamin—undekaprenil-fosfat N-acetilglukozaminfosfotransferaza (EC 2.7.8.33, UDP-N-acetilglukozamin:undekaprenil-fosfat GlcNAc-1-fosfat transferaza, WecA, WecA transferaza, UDP-GIcNAc:undekaprenil fosfat N-acetilglukozaminil 1-P transferaza, GlcNAc-P-P-Und sintaza, GPT, TagO, UDP-GlcNAc:undekaprenil-fosfat GlcNAc-1-fosfat transferaza, UDP-N-acetil-D-glukozamin:ditrans,oktacis-undekaprenil fosfat N-acetilglukozaminfosfotransferaza) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin:ditrans,oktacis-undekaprenil fosfat N-acetil-alfa-D-glukozaminfosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-glukozamin + ditrans,oktacis-undekaprenil fosfat UMP + N-acetil-alfa-D-glukozaminildifosfo-ditrans,oktacis-undekaprenol
Ovaj enzim katalizuje sintezu ditrans,oktacis-undekaprenil-N-acetil-alfa-D-glukozaminil difosfata.
Reference[uredi | uredi kod]
- ↑ Al-Dabbagh, B., Mengin-Lecreulx, D. and Bouhss, A. (2008). „Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA”. J. Bacteriol. 190: 7141-7146. PMID 18723618.
- ↑ Lehrer, J., Vigeant, K.A., Tatar, L.D. and Valvano, M.A. (2007). „Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide”. J. Bacteriol. 189: 2618-2628. PMID 17237164.
- ↑ Rush, J.S., Rick, P.D. and Waechter, C.J. (1997). „Polyisoprenyl phosphate specificity of UDP-GlcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli”. Glycobiology 7: 315-322. PMID 9134438.
- ↑ Soldo, B., Lazarevic, V. and Karamata, D. (2002). „tagO is involved in the synthesis of all anionic cell-wall polymers in Bacillus subtilis 168”. Microbiology 148: 2079-2087. PMID 12101296.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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