UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin transaminaza

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UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin transaminaza
Identifikatori
EC broj 2.6.1.91
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin transaminaza (EC 2.6.1.91, pglE (gen)) je enzim sa sistematskim imenom UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin:2-oksoglutarat aminotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin + 2-oksoglutarat UDP-2-acetamido-2,6-didezoksi-alfa-D-ksilo-heks-4-uloza + L-glutamat

Ovaj enzim je piridoksal-fosfatni protein. Ovaj enzim učestvuje u biosinteza UDP-N,N-diacetilbacilozamina.

Reference[uredi | uredi kod]

  1. Olivier, N.B., Chen, M.M., Behr, J.R. and Imperiali, B. (2006). „In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system”. Biochemistry 45: 13659-13669. PMID 17087520. 
  2. Schoenhofen, I.C., McNally, D.J., Vinogradov, E., Whitfield, D., Young, N.M., Dick, S., Wakarchuk, W.W., Brisson, J.R. and Logan, S.M. (2006). „Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways”. J. Biol. Chem. 281: 723-732. PMID 16286454. 
  3. Rangarajan, E.S., Ruane, K.M., Sulea, T., Watson, D.C., Proteau, A., Leclerc, S., Cygler, M., Matte, A. and Young, N.M. (2008). „Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni”. Biochemistry 47: 1827-1836. PMID 18198901. 
  4. Hartley, M.D., Morrison, M.J., Aas, F.E., Borud, B., Koomey, M. and Imperiali, B. (2011). „Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N′-diacetylbacillosamine”. Biochemistry 50: 4936-4948. PMID 21542610. 

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