UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza
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| UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.203 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza (EC 2.3.1.203, PglD) je enzim sa sistematskim imenom acetil-KoA:UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin N-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + UDP-4-amino-4,6-didezoksi-N-acetil-alfa-D-glukozamin KoA + UDP-N,N'-diacetilbacillosamin
Produkt, UDP-N,N'-diacetilbacilosamin, je intermedijer pri glikozilaciji proteina kod nekoliko bakterijskih vrsta.
Reference[uredi | uredi kod]
- ↑ Olivier, N.B., Chen, M.M., Behr, J.R. and Imperiali, B. (2006). „In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system”. Biochemistry 45: 13659-13669. PMID 17087520.
- ↑ Rangarajan, E.S., Ruane, K.M., Sulea, T., Watson, D.C., Proteau, A., Leclerc, S., Cygler, M., Matte, A. and Young, N.M. (2008). „Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni”. Biochemistry 47: 1827-1836. PMID 18198901.
- ↑ Hartley, M.D., Morrison, M.J., Aas, F.E., Borud, B., Koomey, M. and Imperiali, B. (2011). „Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N′-diacetylbacillosamine”. Biochemistry 50: 4936-4948. PMID 21542610.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.