UDP-3-O-acil-N-acetilglukozaminska deacetilaza

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UDP-3-O-acil-N-acetilglukozaminska deacetilaza
Identifikatori
EC broj 3.5.1.108
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

UDP-3-O-acil-N-acetilglukozaminska deacetilaza (EC 3.5.1.108, LpxC protein, LpxC enzim, LpxC deacetilaza, deacetilaza LpxC, UDP-3-O-acil-GlcNAc deacetilaza, UDP-3-O-((R)-3-hidroksimiristoil)-N-acetilglukozaminska deacetilaza, UDP-(3-O-acil)-N-acetilglukozaminska deacetilaza, UDP-3-O-(R-3-hidroksimiristoil)-N-acetilglukozaminsla deacetilaza, UDP-(3-O-(R-3-hidroksimiristoil))-N-acetilglukozaminsla deacetilaza) je enzim sa sistematskim imenom UDP-3-O-((3R)-3-hidroksimiristoil)-N-acetilglukozamin amidohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-3-O-[(3R)-3-hidroksimiristoil]-N-acetilglukozamin + H2O UDP-3-O-[(3R)-3-hidroksimiristoil]-D-glukozamin + acetat

Ovaj enzim sadrži cink.

Reference[uredi - уреди | uredi izvor]

  1. Hernick, M., Gennadios, H.A., Whittington, D.A., Rusche, K.M., Christianson, D.W. and Fierke, C.A. (2005). "UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism". J. Biol. Chem. 280: 16969–16978. PMID 15705580. 
  2. Jackman, J.E., Raetz, C.R. and Fierke, C.A. (1999). "UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme". Biochemistry 38: 1902–1911. PMID 10026271. 
  3. Hyland, S.A., Eveland, S.S. and Anderson, M.S. (1997). "Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway". J. Bacteriol. 179: 2029–2037. PMID 9068651. 
  4. Wang, W., Maniar, M., Jain, R., Jacobs, J., Trias, J. and Yuan, Z. (2001). "A fluorescence-based homogeneous assay for measuring activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase". Anal. Biochem. 290: 338–346. PMID 11237337. 
  5. Whittington, D.A., Rusche, K.M., Shin, H., Fierke, C.A. and Christianson, D.W. (2003). "Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis". Proc. Natl. Acad. Sci. USA 100: 8146–8150. PMID 12819349. 
  6. Mochalkin, I., Knafels, J.D. and Lightle, S. (2008). "Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor". Protein Sci. 17: 450–457. PMID 18287278. 

Literatura[uredi - уреди | uredi izvor]

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