UDP-2-acetamido-3-amino-2,3-didezoksi-glukuronat N-acetiltransferaza
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| UDP-2-acetamido-3-amino-2,3-didezoksi-glukuronat N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.201 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-2-acetamido-3-amino-2,3-didezoksi-glukuronat N-acetiltransferaza (EC 2.3.1.201, WbpD, WlbB) je enzim sa sistematskim imenom acetil-KoA:UDP-2-acetamido-3-amino-2,3-didezoksi-alfa-D-glukuronat N-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + UDP-2-acetamido-3-amino-2,3-didezoksi-alfa-D-glukuronat KoA + UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-glukuronat
Ovaj enzim učestvuje u biosintezi UDP-alfa-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-manuronske kiseline).
Reference[uredi | uredi kod]
- ↑ Westman, E.L., McNally, D.J., Charchoglyan, A., Brewer, D., Field, R.A. and Lam, J.S. (2009). „Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa”. J. Biol. Chem. 284: 11854-11862. PMID 19282284.
- ↑ Larkin, A. and Imperiali, B. (2009). „Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1”. Biochemistry 48: 5446-5455. PMID 19348502.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.