UDP-2,3-diacetamido-2,3-dideoksiglukuronska kiselina 2-epimeraza
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| UDP-2,3-diacetamido-2,3-dideoksiglukuronska kiselina 2-epimeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.1.3.23 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-2,3-diacetamido-2,3-dideoksiglukuronska kiselina 2-epimeraza (EC 5.1.3.23, UDP-GlcNAc3NAcA 2-epimeraza, UDP-alfa-D-GlcNAc3NAcA 2-epimeraza, 2,3-diacetamido-2,3-didezoksi-alfa-D-glukuronska kiselina 2-epimeraza, WbpI, WlbD) je enzim sa sistematskim imenom 2,3-diacetamido-2,3-didezoksi-alfa-D-glukuronat 2-epimeraza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-glukuronat UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-manuronat
Ovaj enzim učestvuje u biosintezi UDP-alfa-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-manuronske kiseline).
Reference[uredi | uredi kod]
- ↑ Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S. (2007). „Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens”. Biochem. J. 405: 123-130. PMID 17346239.
- ↑ Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S. (2007). „Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens”. Biochem. J. 405: 625-625.
- ↑ Sri Kannathasan, V., Staines, A.G., Dong, C.J., Field, R.A., Preston, A.G., Maskell, D.J. and Naismith, J.H. (2001). „Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2′-epimerase”. Acta Crystallogr. D Biol. Crystallogr. 57: 1310-1312. PMID 11526328.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.