Trimetilamin dehidrogenaza
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| Trimetilamin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.8.2 | ||||||||
| CAS broj | 39307-09-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Trimetilamin dehidrogenaza (EC 1.5.8.2, trimetilaminska dehidrogenaza) je enzim sa sistematskim imenom trimetilamin:elektron-transfer flavoprotein oksidoreduktaza (demetilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- trimetilamin + H2O + elektron-transfer flavoprotein dimetilamin + formaldehid + redukovani elektron-transfer flavoprotein
Znata broj alkil-supstituisanih derivata trimetilamina takođe mogu da deluju kao elektronski donori.
Reference[uredi | uredi kod]
- ↑ Colby, J. and Zatman, L.J. (1971). „The purification and properties of a bacterial trimethylamine dehydrogenase”. Biochem. J. 121: 9P-10P. PMID 5116569.
- ↑ Steenkamp, D.J. and Singer, T.P. (1978). „Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis”. Biochem. J. 169: 361-369. PMID 204297.
- ↑ Huang, L.X., Rohlfs, R.J. and Hille, R. (1995). „The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein”. J. Biol. Chem. 270: 23958-23965. PMID 7592591.
- ↑ Jones, M., Talfournier, F., Bobrov, A., Grossmann, J.G., Vekshin, N., Sutcliffe, M.J. and Scrutton, N.S. (2002). „Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein”. J. Biol. Chem. 277: 8457-8465. PMID 11756429.
- ↑ Scrutton, N.S. and Sutcliffe, M.J. (2000). „Trimethylamine dehydrogenase and electron transferring flavoprotein”. Subcell. Biochem. 35: 145-181. PMID 11192721.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.