Trimetilamin-korinoid protein Co-metiltransferaza
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| Trimetilamin-korinoid protein Co-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.250 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trimetilamin-korinoid protein Co-metiltransferaza (EC 2.1.1.250, mttB (gen), trimetilaminska metiltransferaza) je enzim sa sistematskim imenom trimetilamin:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- trimetilamin + [Co(I) trimetilamin-specifični korinoidni protein] [metil-Co(III) trimetilamin-specifični korinoidni protein] + dimetilamin
Enzim, koji katalizuje transfer metil grupe sa trimetilamina na trimetilamin-specifični korinoidni protein (MttC), učestvuje u metanogenezi. Ovaj enzim sadrži neobičnu aminokiselinu pirolizin.
Reference[uredi | uredi kod]
- ↑ Ferguson, D.J., Jr. and Krzycki, J.A. (1997). „Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri”. J. Bacteriol. 179: 846-852. PMID 9006042.
- ↑ Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484-491. PMID 15450490.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.