Tricin sintaza
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| Tricin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.175 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tricin sintaza (EC 2.1.1.175, ROMT-17, ROMT-15, HvOMT1, ZmOMT1) je enzim sa sistematskim imenom S-adenozil-L-metionin:tricetin 3',5'-O-dimetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + tricetin 2 S-adenozil-L-homocistein + 3',5'-O-dimetiltricetin (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + tricetin S-adenozil-L-homocistein + 3'-O-metiltricetin
- (1b) S-adenozil-L-metionin + 3'-O-metiltricetin S-adenozil-L-homocistein + 3',5'-O-dimetiltricetin
Enzims iz Oryza sativa (ROMT-15 i ROMT-17) katalizuje the metilaciju tricetina do njegovih 3'-mono- i 3',5'-dimetil etara. Za razliku od enzima iz žita (EC 2.1.1.169, tricetin 3',4',5'-O-trimetiltransferaze), ne dolazi do konverzije tricetin dimetil etra u njegove 3',4',5'-trimetilisane derivate. Enzimi iz Hordeum vulgare (HvOMT1) i iz Zea mays (ZmOMT1) prvenstveno formiraju 3',5'-dimetil derivate.
Reference[uredi | uredi kod]
- ↑ Lee, Y.J., Kim, B.G., Chong, Y., Lim, Y. and Ahn, J.H. (2008). „Cation dependent O-methyltransferases from rice”. Planta 227: 641-647. PMID 17943312.
- ↑ Zhou, J.-M., Fukushi, Y., Wollenweber, E., Ibrahim, R.K. (2008). „Characterization of two O-methyltransferase-like genes in barley and maize”. Pharm. Biol. 46: 26-34.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.