Trans-o-hidroksibenzilidenepiruvatna hidrataza-aldolaza
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| Trans-o-hidroksibenzilidenepiruvatna hidrataza-aldolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.2.45 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Trans-o-hidroksibenzilidenepiruvatna hidrataza-aldolaza (EC 4.1.2.45, 2'-hidroksibenzalpiruvat aldolaza, NsaE, tHBPA hidrataza-aldolaza) je enzim sa sistematskim imenom (3E)-4-(2-hidroksifenil)-2-oksobut-3-enoat hidro-lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (3E)-4-(2-hidroksifenil)-2-oksobut-3-enoat + H2O salicilaldehid + piruvat
Ovaj enzim učestvuje u degradaciji naftalena
Reference[uredi | uredi kod]
- ↑ Kuhm, A.E., Knackmuss, H.J. and Stolz, A. (1993). „Purification and properties of 2′-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates”. J. Biol. Chem. 268: 9484-9489. PMID 8486638.
- ↑ Keck, A., Conradt, D., Mahler, A., Stolz, A., Mattes, R. and Klein, J. (2006). „Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6”. Microbiology 152: 1929-1940. PMID 16804169.
- ↑ Eaton, R.W. (1994). „Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid”. J. Bacteriol. 176: 7757-7762. PMID 8002605.
- ↑ Eaton, R.W. (2000). „trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst”. Appl. Environ. Microbiol. 66: 2668-2672. PMID 10831455.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.