Tirozinska proteinska kinaza CSK

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C-src tirozinska kinaza
Dostupne strukture
1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ
Identifikatori
Simboli CSK; MGC117393
Vanjski ID OMIM124095 MGI88537 HomoloGene55818 GeneCards: CSK Gene
EC broj 2.7.10.2
Pregled RNK izražavanja
PBB GE CSK 202329 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1445 12988
Ensembl ENSG00000103653 ENSMUSG00000032312
UniProt P41240 P41241
Ref. Sekv. (iRNK) NM_001127190 NM_007783
Ref. Sekv. (protein) NP_001120662 NP_031809
Lokacija (UCSC) Chr 15:
74.78 - 74.8 Mb
Chr 9:
57.63 - 57.65 Mb
PubMed pretraga [1] [2]

Tirozinska proteinska kinaza CSK (C-Src kinaza, C-terminalna Src kinaza) enzim je koji je kod ljudi kodiran CSK genom.[1] Ovaj enzim fosforilizuje tirozinske ostatke locirane na C-terminalnom kraju Src familije kinaza (SFK) uključujući SRC, HCK, FYN, LCK, LYN i YES1.[2][3]

Funkcija[uredi - уреди | uredi izvor]

Tirozinska proteinska kinaza CSK supresuje dejstvo Src familije proteinskih kinaza putem fosforilacije članova Src familije na konuerviranom C-terminalnom mestu u Src.[4][5][6][7] Za Csk kontrolu dejstva Src familije se smatra da ima centralno mesto u regulaciji imunskog responsa.[8] Src takođe reguliše angiogene faktore i vaskularnu permeabilnost nakon fokalne cerebralne ischemijske reperfuzije.[9][10]

Klinički značaj[uredi - уреди | uredi izvor]

Csk interakcija sa fosfatazom ("Lyp", genski produkt PTPN22) acociran je sa povišenom zastupljenošću autoimunskih bolesti vezanih za PTPN22 mutacije.[11]

Reference[uredi - уреди | uredi izvor]

  1. "Entrez Gene: C-src tyrosine kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=1445. pristupljeno 2013-07-11. 
  2. Bergman M, Mustelin T, Oetken C, Partanen J, Flint NA, Amrein KE, Autero M, Burn P, Alitalo K (August 1992). "The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity". EMBO J. 11 (8): 2919–24. PMC 556773. PMID 1639064. 
  3. Sun G, Budde RJ (September 1997). "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system". Arch. Biochem. Biophys. 345 (1): 135–42. PMID 9281320. doi:10.1006/abbi.1997.0236. 
  4. Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H (May 1991). "Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src". Nature 351 (6321): 69–72. PMID 1709258. doi:10.1038/351069a0. 
  5. Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S (June 1993). "Constitutive activation of Src family kinases in mouse embryos that lack Csk". Cell 73 (6): 1125–35. PMID 8513497. doi:10.1016/0092-8674(93)90642-4. 
  6. Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC (November 2006). "C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases". J. Biol. Chem. 281 (44): 32988–99. PMID 16959780. doi:10.1074/jbc.M602951200. 
  7. Chong YP, Mulhern TD, Cheng HC (September 2005). "C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases". Growth Factors 23 (3): 233–44. PMID 16243715. doi:10.1080/08977190500178877. 
  8. Latour S, Veillette A (June 2001). "Proximal protein tyrosine kinases in immunoreceptor signaling". Curr. Opin. Immunol. 13 (3): 299–306. PMID 11406361. doi:10.1016/S0952-7915(00)00219-3. 
  9. Zan L, Wu H, Jiang J, Zhao S, Song Y, Teng G, Li H, Jia Y, Zhou M, Zhang X, Qi J, Wang J. (July 2011). "Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema". Neurochem Int. 58 (8): 872–9. PMC 3100427. PMID 21334414. doi:10.1016/j.neuint.2011.02.014. 
  10. Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J. (March 2014). "Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion.". Neuroscience. 262 (3): 118–128. PMID 24412374. doi:10.1016/j.neuroscience.2013.12.060. 
  11. Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N (August 2010). "Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue". J. Biol. Chem. 285 (34): 26506–18. PMC 2924087. PMID 20538612. doi:10.1074/jbc.M110.111104. 

Vanjske veze[uredi - уреди | uredi izvor]