Tiazol sintaza
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| Tiazol sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Tiazol sintaza homooktamer, Saccharomyces cerevisiae | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.8.1.10 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Tiazol sintaza (EC 2.8.1.10, thiG (gen)) je enzim sa sistematskim imenom 1-dezoksi-D-ksiluloza 5-fosfat:tiol sumportransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-dezoksi-D-ksiluloza 5-fosfat + 2-iminoacetat + tiokarboksi-adenilat-[sumpor-nosilac protein ThiS] 2-[(2R,5Z)-2-karboksi-4-metiltiazol-5(2H)-iliden]etil fosfat + [sumpor-nosilac protein ThiS] + 2H2O
H2S može da obezbedi sumpor in vitro.
Reference[uredi | uredi kod]
- ↑ Park, J.H., Dorrestein, P.C., Zhai, H., Kinsland, C., McLafferty, F.W. and Begley, T.P. (2003). „Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1)”. Biochemistry 42: 12430-12438. PMID 14567704.
- ↑ Dorrestein, P.C., Zhai, H., McLafferty, F.W. and Begley, T.P. (2004). „The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS”. Chem. Biol. 11: 1373-1381. PMID 15489164.
- ↑ Dorrestein, P.C., Zhai, H., Taylor, S.V., McLafferty, F.W. and Begley, T.P. (2004). „The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase”. J. Am. Chem. Soc. 126: 3091-3096. PMID 15012138.
- ↑ Settembre, E.C., Dorrestein, P.C., Zhai, H., Chatterjee, A., McLafferty, F.W., Begley, T.P. and Ealick, S.E. (2004). „Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex”. Biochemistry 43: 11647-11657. PMID 15362849.
- ↑ Hazra, A., Chatterjee, A. and Begley, T.P. (2009). „Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction”. J. Am. Chem. Soc. 131: 3225-3229. PMID 19216519.
- ↑ Hazra, A.B., Han, Y., Chatterjee, A., Zhang, Y., Lai, R.Y., Ealick, S.E. and Begley, T.P. (2011). „A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase”. J. Am. Chem. Soc. 133: 9311-9319. PMID 21534620.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.