Tau-protein kinaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Tau-protein kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.11.26 | ||||||||
| CAS broj | 111694-09-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tau-protein kinaza (EC 2.7.11.26, ATP:tau-protein O-hosfotransferaza, moždana proteinska kinaza PK40erk, cdk5/p20, CDK5/p23, glikogenska sintaza kinaza-3beta, GSK, protein tau kinaza, STK31, tau kinaza, tau-protein kinaza I, tau-protein kinaza II, tau-tubulin kinaza, TPK, TPK I, TPK II, TTK) je enzim sa sistematskim imenom ATP:(tau-protein) O-fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim se aktivira tubulinom.
Reference[uredi | uredi kod]
- ↑ Ishiguro, K., Ihara, Y., Uchida, T. and Imahori, K. (1988). „A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau”. J. Biochem. (Tokyo) 104: 319-321. PMID 2467901.
- ↑ Lund, E.T., McKenna, R., Evans, D.B., Sharma, S.K. and Mathews, W.R. (2001). „Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry”. J. Neurochem. 76: 1221-1232. PMID 11181841.
- ↑ Michel, G., Mercken, M., Murayama, M., Noguchi, K., Ishiguro, K., Imahori, K. and Takashima, A. (1998). „Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells”. Biochim. Biophys. Acta 1380: 177-182. PMID 9565682.
- ↑ Aoki, M., Iwamoto-Sugai, M., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Sugio, S., Kohno, T. and Matsuzaki, T. (2000). „Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta”. Acta Crystallogr. D Biol. Crystallogr. 56: 1464-1465. PMID 11053853.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.