Taksan 10b-hidroksilaza
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| Taksan 10b-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.76 | ||||||||
| CAS broj | 337514-75-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Taksan 10b-hidroksilaza (EC 1.14.13.76, taksanska 10b-hidroksilaza) je enzim sa sistematskim imenom taksa-4(20),11-dien-5alfa-il acetat,NADPH:kiseonik oksidoreduktaza (10beta-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- taksa-4(20),11-dien-5alfa-il acetat + NADPH + H+ + O2 10beta-hidroksitaksa-4(20),11-dien-5alfa-il acetat + NADP+ +H2O
Ovaj mikrozomalni citohrom-P450-zavisni enzim učestvuje u biosinteza diterpenoidnog antineoplastičnog leka taksola (paklitaksela).
Reference[uredi | uredi kod]
- ↑ Wheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M. and Croteau, R. (2001). „Taxol biosynthesis: differential transformations of taxadien-5α-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells”. Arch. Biochem. Biophys. 390: 265-78. PMID 11396929.
- ↑ Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Taxol biosynthesis: taxane 13 α-hydroxylase is a cytochrome P450-dependent monooxygenase”. Proc. Natl. Acad. Sci. USA 98: 13595-13560. PMID 11707604.
- ↑ Schoendorf, A., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Molecular cloning of a cytochrome P450 taxane 10β-hydroxylase cDNA from Taxus and functional expression in yeast”. Proc. Natl. Acad. Sci. USA 98: 1501-1506. PMID 11171980.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.