TRNK pseudouridinska32 sintaza
Prijeđi na navigaciju
Prijeđi na pretragu
| TRNK pseudouridinska32 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.28 | ||||||||
| CAS broj | 430429-15-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK pseudouridinska32 sintaza (EC 5.4.99.28, RluA, pseudouridin sintaza RluA, Pus9p, Rib2/Pus8p) je enzim sa sistematskim imenom tRNK-uridin32 uracil mutaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tRNK uridin32 tRNK pseudouridin32
Ovaj dualno specifični enzim iz Escherichia coli takođe katalizuje formiranje pseudouridina746 u molekulu 23S rRNK.
Reference[uredi | uredi kod]
- ↑ Hoang, C., Chen, J., Vizthum, C.A., Kandel, J.M., Hamilton, C.S., Mueller, E.G. and Ferre-D'Amare, A.R. (2006). „Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure”. Mol. Cell 24: 535-545. PMID 17188032.
- ↑ Spedaliere, C.J., Hamilton, C.S. and Mueller, E.G. (2000). „Functional importance of motif I of pseudouridine synthases: mutagenesis of aligned lysine and proline residues”. Biochemistry 39: 9459-9465. PMID 10924141.
- ↑ Raychaudhuri, S., Niu, L., Conrad, J., Lane, B.G. and Ofengand, J. (1999). „Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA”. J. Biol. Chem. 274: 18880-18886. PMID 10383384.
- ↑ Ramamurthy, V., Swann, S.L., Spedaliere, C.J. and Mueller, E.G. (1999). „Role of cysteine residues in pseudouridine synthases of different families”. Biochemistry 38: 13106-13111. PMID 10529181.
- ↑ Wrzesinski, J., Nurse, K., Bakin, A., Lane, B.G. and Ofengand, J. (1995). „A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for Ψ746 in 23S RNA is also specific for Ψ32 in tRNAPhe”. RNA 1: 437-448. PMID 7493321.
- ↑ Behm-Ansmant, I., Grosjean, H., Massenet, S., Motorin, Y. and Branlant, C. (2004). „Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae”. J. Biol. Chem. 279: 52998-53006. PMID 15466869.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.