TRNK nukleotidiltransferaza
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| TRNK nukleotidiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Heksamer RNaze PH (Pseudomonas aeruginosa) | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.56 | ||||||||
| CAS broj | 116412-36-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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TRNK nukleotidiltransferaza (EC 2.7.7.56, fosfat-zavisna eksonukleaza, RNaza PH, ribonukleaza PH) je enzim sa sistematskim imenom tRNK:fosfat nukleotidiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tRNKn+1 + fosfat tRNKn + nukleozid difosfat
Ovaj enzim vrši finalno eksonukleolitičko odsecanje na 3'-terminusu tRNK prekursora kod Escherichia coli putem fosforolize.
Reference[uredi | uredi kod]
- ↑ Cudny, H. and Deutscher, M.P. (1988). „3′ processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement”. J. Biol. Chem. 263: 1518-1523. PMID 3275667.
- ↑ Deutscher, M.P., Marshall, G.T. and Cudny, H. (1988). „RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase”. Proc. Natl. Acad. Sci. USA 85: 4710-4714. PMID 2455297.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.