TRNK intron endonukleaza
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| TRNK intron endonukleaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.27.9 | ||||||||
| CAS broj | 117444-13-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK intron endonukleaza (EC 3.1.27.9, transferna ribonukleat intronska endoribonukleaza, tRNK splajsujuća endonukleaza, splajsujuća endonukleaza, tRNKTRPintron endonukleaza, transferna splajsujuća endonukleaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endonukleolitičko razlaganje pre-tRNK, formiranje 5'-hidroksi i 2',3'-ciklično fosfatnih krajeva, i specifično uklanjanje introna
Ovaj enzim katalizuje finalni stupanj maturacije tRNK molekula.
Reference[uredi | uredi kod]
- ↑ Attardi, D.G., Margarit, I. and Tocchini-Valentini, G.P. (1985). „Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease”. EMBO J. 4: 3289-3297. PMID 3937725.
- ↑ Peebles, C.L., Gegenheimer, P. and Abelson, J. (1983). „Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease”. Cell 32: 525-536. PMID 6186398.
- ↑ Thompson, L.D., Brandon, L.D., Nieuwlandt, D.T. and Daniels, C.J. (1989). „Transfer RNA intron processing in the halophilic archaebacteria”. Can. J. Microbiol. 35: 36-42. PMID 2470486.
- ↑ Thompson, L.D. and Daniels, C.J. (1988). „A tRNA(Trp) intron endonuclease from Halobacterium volcanii. Unique substrate recognition properties”. J. Biol. Chem. 263: 17951-17959. PMID 3192521.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.