TRNK (guanin10-N2)-metiltransferaza
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| tRNK (guanin10-N2)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.214 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
tRNK (guanin10-N2)-metiltransferaza (EC 2.1.1.214, (m2G10) metiltransferaza, Trm11-Trm112 kompleks) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin10-N2)-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin10 u tRNK S-adenozil-L-homocistein + N2-metilguanin10 u tRNK
Za razliku od arhejskog enzima, tRNK (guanin10-N2)-dimetiltransferaze (EC 2.1.1.213), tRNK (guanin10-N2)-metiltransferaza iz kvasca ne katalizuje metilaciju N2-metilguanina10 do N2-dimetilguanina10 u tRNK.
Reference[uredi | uredi kod]
- ↑ Purushothaman, S.K., Bujnicki, J.M., Grosjean, H. and Lapeyre, B. (2005). „Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA”. Mol. Cell Biol. 25: 4359-4370. PMID 15899842.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.