TRNK (citozin38-C5)-metiltransferaza
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| TRNK (citozin38-C5)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.204 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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TRNK (citozin38-C5)-metiltransferaza (EC 2.1.1.204, hDNMT2 (gen), DNMT2 (gen), TRDMT1 (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (citozin38-C5)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + citozin38 u tRNK S-adenozil-L-homocistein + 5-metilcitozin38 u tRNK
Eukariotski enzim katalizuje metilaciju citozina38 u anti-kodonskoj petlji tRNKAsp(GTC), tRNKVal(AAC) i tRNKGly(GCC). Metilacija posredstvom Dnmt2 enzima štiti tRNK molekule protiv stresom indukovanog odsecanja ribonukleazom.
Reference[uredi | uredi kod]
- ↑ Goll, M.G., Kirpekar, F., Maggert, K.A., Yoder, J.A., Hsieh, C.L., Zhang, X., Golic, K.G., Jacobsen, S.E. and Bestor, T.H. (2006). „Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2”. Science 311: 395-398. PMID 16424344.
- ↑ Jurkowski, T.P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. and Jeltsch, A. (2008). „Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism”. RNA 14: 1663-1670. PMID 18567810.
- ↑ Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. and Lyko, F. (2010). „RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage”. Genes Dev. 24: 1590-1595. PMID 20679393.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.