TRNK-dihidrouridin 20 sintaza (NAD(P)+)
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| TRNA-dihidrouridin 20 sintaza [NAD(P)+] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.91 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
tRNK-dihidrouridin 20 sintaza [NAD(P)+] (EC 1.3.1.91, Dus2p, tRNK-dihidrouridinska sintaza 2) je enzim sa sistematskim imenom tRNK-5,6-dihidrouracil20:NAD(P)+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5,6-dihidrouracil 20 u tRNK + NAD(P)+ uracil 20 u tRNK + NAD(P)H + H+
Ovaj enzim je flavoenzim. On specifično modifikuje uracil 20 u tRNK.
Reference[uredi | uredi kod]
- ↑ Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. (2004). „The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs”. J. Biol. Chem. 279: 17850-17860. PMID 14970222.
- ↑ Xing, F., Martzen, M.R. and Phizicky, E.M. (2002). „A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA”. RNA 8: 370-381. PMID 12003496.
- ↑ Rider, L.W., Ottosen, M.B., Gattis, S.G. and Palfey, B.A. (2009). „Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction”. J. Biol. Chem. 284: 10324-10333. PMID 19139092.
- ↑ Kato, T., Daigo, Y., Hayama, S., Ishikawa, N., Yamabuki, T., Ito, T., Miyamoto, M., Kondo, S. and Nakamura, Y. (2005). „A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis”. Cancer Res. 65: 5638-5646. PMID 15994936.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.