TRIO (gen)

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Faktor razmene trio ro guanina

PDB prikaz baziran na 1nty.
Dostupne strukture
1NTY, 2NZ8
Identifikatori
SimboliTRIO; ARHGEF23; tgat
Vanjski IDOMIM601893 MGI1927230 HomoloGene20847 GeneCards: TRIO Gene
EC broj2.7.11.1
Pregled RNK izražavanja
PBB GE TRIO 209012 at tn.png
PBB GE TRIO 208178 x at tn.png
PBB GE TRIO 209010 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez7204223435
EnsemblENSG00000038382ENSMUSG00000022263
UniProtO75962Q0KL02
RefSeq (mRNA)NM_007118.2NM_001081302.1
RefSeq (protein)NP_009049.2NP_001074771.1
Lokacija (UCSC)Chr 5:
14.14 - 14.53 Mb
Chr 15:
27.73 - 28.03 Mb
PubMed pretraga[1][2]

Protein trofunkcionog domena (engl. Triple functional domain protein) je protein koji je kod ljudi kodiran TRIO genom.[1][2]

Interakcije[uredi - уреди | uredi izvor]

TRIO (gen) formira interakcije sa filaminom[3] i RHOA.[4]

Reference[uredi - уреди | uredi izvor]

  1. Debant A, Serra-Pages C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (July 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proc Natl Acad Sci U S A 93 (11): 5466–71. PMC 39269. PMID 8643598. doi:10.1073/pnas.93.11.5466. 
  2. "Entrez Gene: TRIO triple functional domain (PTPRF interacting)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7204. 
  3. Bellanger, J M; Astier C, Sardet C, Ohta Y, Stossel T P, Debant A (December 2000). "The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin". Nat. Cell Biol. (ENGLAND) 2 (12): 888–92. ISSN 1465-7392. PMID 11146652. doi:10.1038/35046533. 
  4. Medley, Q G; Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien S P, Streuli M (November 2000). "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". J. Biol. Chem. (UNITED STATES) 275 (46): 36116–23. ISSN 0021-9258. PMID 10948190. doi:10.1074/jbc.M003775200. 

Literatura[uredi - уреди | uredi izvor]