Transkriptioni faktor II E

Opšti transkripcioni faktor IIE, polipeptid 1, alfa 56 kDa
Identifikatori
Simbol	GTF2E1
Alt. simboli	TF2E1
Entrez	2960
HUGO	4650
OMIM	189962
RefSeq	NM_005513
UniProt	P29083
Drugi podaci
Lokus	Hromozom 3 q21-q24

Opšti transkripcioni faktor IIE, polipeptid 2, beta 34 kDa
Identifikatori
Simbol	GTF2E2
Alt. simboli	TF2E2
Entrez	2961
Hugo	4651
OMIM	189964
RefSek	NM_002095
UniProt	P29084
Drugi podaci
Lokus	Hrom. 8 p12

Transkripcioni faktor II E (TF_IIE) je jedan od nekoliko opštih transkripcionih faktora koji sačinjavaju preinicijacioni kompleks RNK polimeraze II.^[1]

Transkripcioni faktor II E je kodiran GTF2E1 i GTF2E2 genima.^[2]^[3]^[4]^[5] TFIIE učestvuje u DNK otapanju na promoteru: on sadrži trakasti motiv zinka koji može da se veže za jednolančanu DNK.^[6]

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Reference[uredi | uredi kod]

↑ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. str. p636–637. ISBN 0-13-144946-X.
↑ Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M (1992). „Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences”. Nucleic Acids Res. 20 (21): 5838. DOI:10.1093/nar/20.21.5838. PMC 334425. PMID 1454543.
↑ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). „Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome”. Hum. Mol. Genet. 3 (1): 61–4. DOI:10.1093/hmg/3.1.61. PMID 8162052.
↑ Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG (1991). „Conserved sequence motifs in the small subunit of human general transcription factor TFIIE”. Nature 354 (6352): 401–4. DOI:10.1038/354401a0. PMID 1956404.
↑ Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG (December 1991). „Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE”. Nature 354 (6352): 398–401. DOI:10.1038/354398a0. PMID 1956403.
↑ Lee TI, Young RA (2000). „Transcription of eukaryotic protein-coding genes”. Annu. Rev. Genet. 34: 77–137. DOI:10.1146/annurev.genet.34.1.77. PMID 11092823.

Spoljašnje veze[uredi | uredi kod]

MeSH Transcription+Factor+TFIIE

Ćelijska komunikacija

Ključni koncepti

Transdukcija signala • Apoptoza • Sistemi sekundarnih glasnika (Ca²⁺ signalizacija, Lipidna signalizacija, Kvorum očitavanje)

Procesi

Parakrini • Autokrini • Jukstakrini • Neurotransmiteri • Endokrini (Neuroendokrini) • Intrakrini

Signalni putevi

Hedgehog signalni put • Wnt signalni put • TGF beta signalni put • MAPK/ERK put • Notch signalni put • JAK-STAT signalni put • cAMP zavisni put • Akt/PKB signalni put • Fas apoptozni signalni put • Hippo signalni put • IP3/DAG put

Agensi

Ligandi	Hormoni • Neurotransmiteri • Citokini • Faktori rasta
Receptor	Transmembranski • Intracelularni
Transkripcioni faktori	Generalni • Preinicijacioni kompleks • TFIID, TFIIH
Drugi	Adapter protein • Protein osnove

Transkripcioni faktori i intracelularni receptori

(1) Osnovni domeni

(1.1) Osnovni leucin rajsferšlus (bZIP)	Aktivirajući transkripcioni faktor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NFIL3 • NRL • NRF1 • XBP1
(1.2) Osnovni heliks-petlja-heliks (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatorni faktori (MyoD, Myogenin, MYF5, MYF6) • Neurogenini (1, 2, 3) • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Pho4 • Scleraxis • TAL (1, 2) • Twist • USF1
(1.3) bHLH-ZIP	AP-4 • MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.4) NF-1	NFI (A, B, C, X) • SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)
(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)
(1.6) Osnovni heliks-razmak-heliks (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Cink prst DNA-vezujući domeni

(2.1) Nuklearni receptor (Cys₄)	podfamilija 1 (Tiroidni hormon (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX) podfamilija 3 (Steroidni hormon (Androgen, Estrogen (α, β), Glukokortikoid, Mineralokortikoid, Progesteron), Estrogen-vezani (α, β, γ)) podfamilija 4 NUR (NGFIB, NOR1, NURR1) • podfamilija 5 (LRH-1, SF1) • podfamilija 6 (GCNF) • podfamilija 0 (DAX1, SHP)
(2.2) Drugi Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3) • TRPS1
(2.3) Cys₂His₂	Generalni transkripcioni faktori (TFIIA, TFIIB, TFIID, TFIIE, TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 • BCL (6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • GFI1 • GLI-Kruppel familija (1, 2, 3, REST, S2, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17) • MTF1 • MYT1 • OSR1 • SP (1, 2, 4, 7) • WT1 • Zbtb7 (7A, 7B) • ZBTB (16, 17, 20, 32, 33, 40) • cink prst (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
(2.4) Cys₆	HIVEP1
(2.5) Naizmenična kompozicija	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Heliks-zavoj-heliks domeni

(3.1) Homeodomen	ARX • CDX (1, 2) • CRX • CUTL1 • DBX (1, 2) • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • IRX (1, 2, 3, 4, 5, 6, MKX) • LMX (1A, 1B) • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) • PBX (1, 2, 3) • PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) • PITX (1, 2, 3) • POU domen (PIT-1, BRN-3: A, B, C, Oktamer transkripcioni faktor: 1, 2, 3/4, 6, 7, 11) • OTX (1, 2) • PDX1 • ZEB (1, 2)
(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork glava / winged heliks	E2F (1, 2, 3, 4, 5) • FOX proteini (C1, C2, D3, E1, G1, H1, K2, L2, M1, N3, O1, O3, O4, P1, P2, P3)
(3.4) Faktori toplotnog šoka	HSF (1, 2, 4)
(3.5) Triptofan klasteri	ELF (2, 4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2, SPIB) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatorni faktori (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domen	transkripcioni pojačivač faktor (1, 2, 3, 4)

(4) β-Scaffold faktori sa manjim žljebnim kontaktima

(4.1) Rel homologni region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)
(4.3) p53	p53 • TBX (1, 2, 3, 5, 19, 21, 22, Brahiuri, TBR1)
(4.4) MADS kutija	Mef2 (A, B, C, D) • SRF
(4.6) TATA vezujući proteini	TBP • TBPL1
(4.7) Grupa visoke pokretljivosti	HMGB (1, 2, 3) • HNF (1A, 1B) • LEF1 • SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) • SRY • SSRP1 • TCF (3, 4) • TOX (1, 2, 3, 4)
(4.10) Domen hladnog šoka	CSDA, YBX1
(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Drugi transkripcioni faktori

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1
(0.3) Džep domen	Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-vezani faktori	Apetala 2 • EREBP • B3
(0.6) Razno	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFY (A, B, C) • Ro/Sigma

vidi isto transkripcioni faktor/koregulator nedostataka

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