Sve-trans-fitoen sintaza
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| Sve-trans-fitoen sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.99 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sve-trans-fitoen sintaza (EC 2.5.1.99, prefitoen-difosfat sintaza, fitoenska sintetaza, PSaza, geranilgeranil-difosfat geranilgeraniltransferaza, 15-trans-fitoenska sintaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:geranilgeranil-difosfat geranilgeraniltransferaza (formira sve-trans-fitoen).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 geranilgeranil difosfat sve-trans-fitoen + 2 difosfat (sveukupna reakcija)
- (1a) 2 geranilgeranil difosfat difosfat + prefitoen difosfat
- (1b) prefitoen difosfat sve-trans-fitoen + difosfat
Za dejstvo ovog enzima je neophodan jon Mn2+. Enzim iz bakterije Pantoea agglomerans formira sve-trans izomer fitoena.
Reference[uredi | uredi kod]
- ↑ Gregonis, D.E. and Rilling, H.C. (1974). „The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene”. Biochemistry 13: 1538-1542. PMID 4819767.
- ↑ Iwata-Reuyl, D., Math, S.K., Desai, S.B. and Poulter, C.D. (2003). „Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase”. Biochemistry 42: 3359-3365. PMID 12641468.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.