Sukcinat-semialdehid dehidrogenaza (NADP+)
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| Sukcinat-semialdehid dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.79 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sukcinat-semialdehid dehidrogenaza (NADP+) (EC 1.2.1.79, sukcinska semialdehidna dehidrogenaza (NADP+), sukcinil semialdehidna dehidrogenaza (NADP+), sukcinat semialdehid:NADP+ oksidoreduktaza, NADP-zavisni sukcinat-semialdehid dehidrogenaza, GabD) je enzim sa sistematskim imenom sukcinat-semialdehid:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sukcinat semialdehid + NADP+ +H2O sukcinat + NADPH + 2 H+
Ovaj enzim učestvuje u degradaciji glutamata i 4-aminobutirata. On je sličan sa EC 1.2.1.24 (sukcinat-semialdehidnom dehidrogenazom (NAD+)), i EC 1.2.1.16 (sukcinat-semialdehidnom dehidrogenazom (NAD(P)+)), ali je specifičan za NADP+. Enzim iz Escherichia coli je 20-puta aktivniji sa NADP+ nego NAD+.
Reference[uredi | uredi kod]
- ↑ Bartsch, K., von Johnn-Marteville, A. and Schulz, A. (1990). „Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD)”. J. Bacteriol. 172: 7035-7042. PMID 2254272.
- ↑ Jaeger, M., Rothacker, B. and Ilg, T. (2008). „Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases”. Biochem. Biophys. Res. Commun. 372: 400-406. PMID 18474219.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.