Stromelizin-1

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Stromelizin-1
Identifikatori
EC broj 3.4.24.17
CAS broj 79955-99-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Stromelizin-1 (EC 3.4.24.17, matriks metaloproteinaza 3, proteoglikanaza, kolagenaza aktivacinog protein, prokolagenazni aktivator, tranzin, MMP-3, neutralna proteoglikanaza, stromelizin, kolagen-aktivirajući protein) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno razlaganje na mestima gde su P1', P2' i P3' hidrofobni ostaci

Ova ekstracelularna endopeptidaza je prisutna u tkivu kičmenjaka.

Reference[uredi - уреди | uredi izvor]

  1. Chin, J.R., Murphy, G. and Werb, Z. (1985). "Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates". J. Biol. Chem. 260: 12367–12376. PMID 2995374. 
  2. Okada, Y., Nagase, H. and Harris, E.D., Jr. (1986). "A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization". J. Biol. Chem. 261: 14245–14255. PMID 3095317. 
  3. Docherty, A.J.P. and Murphy, G. (1990). "The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins". Ann. Rheum. Dis. 49: 469–479. PMID 2197998. 
  4. Emonard, H. and Grimaud, J.-A. (1990). "Matrix metalloproteinase. A review". Cell. Mol. Biol. 36: 131–153. PMID 2165861. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]