Sfinganin C4-monooksigenaza
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| Sfinganin C4-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.169 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sfinganin C4-monooksigenaza (EC 1.14.13.169, sfingolipidna C4-hidroksilaza, SUR2 (gen), SBH1 (gen), SBH2 (gen)) je enzim sa sistematskim imenom sfinganin,NADPH:kiseonik oksidoreduktaza (C4-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sfinganin + NADPH + H+ + O2 fitosfingozin + NADP+ + H2O
Ovaj enzim učestvuje u biosintezi sfingolipida kod kvasca i biljki.
Reference[uredi | uredi kod]
- ↑ Haak, D., Gable, K., Beeler, T. and Dunn, T. (1997). „Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p”. J. Biol. Chem. 272: 29704-29710. PMID 9368039.
- ↑ Grilley, M.M., Stock, S.D., Dickson, R.C., Lester, R.L. and Takemoto, J.Y. (1998). „Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae”. J. Biol. Chem. 273: 11062-11068. PMID 9556590.
- ↑ Sperling, P., Ternes, P., Moll, H., Franke, S., Zahringer, U. and Heinz, E. (2001). „Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana”. FEBS Lett 494: 90-94. PMID 11297741.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.