Sarkozin reduktaza
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| Sarkozin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.4.3 | ||||||||
| CAS broj | 125752-88-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sarkozin reduktaza (EC 1.21.4.3) je enzim sa sistematskim imenom acetil-fosfat metilamin:tioredoksin disulfid oksidoreduktaza (formira N-metilglicin).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil fosfat + metilamin + tioredoksin disulfid + H2O N-metilglicin + fosfat + tioredoksin
Reakcija se odvija u smeru redukcije sarkozina. Enzim iz Eubakterija kiselinaaminophilum sadrži podjedinice A, B i C. Podjedinica B sadrži selenocistein i piruvoilnu grupu, i odgovorna je za vezivanje sarkozina i otpuštanje metilamina.
Reference[uredi | uredi kod]
- ↑ Wagner, M., Sonntag, D., Grimm, R., Pich, A. Eckerskorn, C., Söhling, B. and Andreesen, J.R. (1999). „Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum”. Eur. J. Biochem. 260: 38-49. PMID 10091582.
- ↑ Hormann, K. and Andreesen, J.R. (1989). „Reductive cleavage of sarcosine and betaine by Eubacterium acidaminophilum via enzyme systems different from glycine reductase”. Arch. Microbiol. 153: 50-59.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.