Salutaridinol 7-O-acetiltransferaza
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Salutaridinol 7-O-acetiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.3.1.150 | ||||||||
CAS broj | 156859-13-1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Salutaridinol 7-O-acetiltransferaza (EC 2.3.1.150) je enzim sa sistematskim imenom acetil-KoA:salutaridinol 7-O-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + salutaridinol KoA + 7-O-acetilsalutaridinol
Ovaj enzim je prisutan u maku, Papaver somniferum. Pri pH 8-9 produkt, 7-O-acetilsalutaridinol, spontano prelazi u 4->5 oksid uglavnom putem alilne eliminacije čime se formira morfinski prekurzor tebain.
Reference[uredi | uredi kod]
- ↑ Lenz, R., Zenk, M.H. (1994). „Closure of the oxide bridge in morphine biosynthesis”. Tetrahedron Lett. 35: 3897-3900.
- ↑ Lenz, R., Zenk, M.H. (1995). „Acetyl-CoA:salutaridinol 7-O-acetyltransferase from Papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis”. J. Biol. Chem. 270: 31091-31096. PMID 8537369.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.