S-14,671

S-14,671
(IUPAC) ime
	N-{2-[4-(7-metoksinaftalen-1-il)piperazin-1-il]etil}tiofen-2-karboksamid
Klinički podaci
Identifikatori
CAS broj	135722-27-9
ATC kod	nije dodeljen
PubChem	131907
ChemSpider	116529
Hemijski podaci
Formula	C22H25N3O2S
Mol. masa	395,52 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C22H25N3O2S/c1-27-18-8-7-17-4-2-5-20(19(17)16-18)25-13-11-24(12-14-25)10-9-23-22(26)21-6-3-15-28-21/h2-8,15-16H,9-14H2,1H3,(H,23,26) ; Key: YFNZHCXOYLKDGU-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

S-14,671 je naftilpiperazinski derivat koji deluje kao agonist 5-HT_1A receptora (pK_i = 9.3) sa visokom efikasnošću i izuzetnom in vivo potencijom. On je isto tako antagonist 5-HT_2A i 5-HT_2C receptor (oba imaju pK_i = 7.8).^[4]^[5] On pokazuje samo nizak afinitet za 5-HT_1B i 5-HT₃ receptore.^[5]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Millan MJ, Canton H, Rivet JM, Lejeune F, Laubie M, Lavielle G (October 1991). „S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency”. European Journal of Pharmacology 203 (2): 319–22. DOI:10.1016/0014-2999(91)90734-8. PMID 1839284.
↑ ^5,0 ^5,1 Millan MJ, Rivet JM, Canton H, et al. (August 1992). „S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors”. The Journal of Pharmacology and Experimental Therapeutics 262 (2): 451–63. PMID 1323650.

	Portal Medicina
	Portal Hemija