Rodopsin kinaza

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Rodopsin kinaza
Identifikatori
EC broj 2.7.11.14
CAS broj 54004-64-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Rodopsin kinaza (EC 2.7.11.14, kupasti opsin kinaza, G-protein-spregnuti receptor kinaza 1, GPCR kinaza 1, GRK1, GRK7, opsinska kinaza, opsinska kinaza (fosforilacija), rodopsinska kinaza (fosforilacija), RK, STK14) je enzim sa sistematskim imenom ATP:rodopsin fosfotransferaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + rodopsin ADP + fosforhodopsin

G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).

Reference[uredi - уреди | uredi izvor]

  1. Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). "Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase". Nature 321: 869–872. PMID 3014340. 
  2. Shichi, H. and Somers, R.L. (1978). "Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase". J. Biol. Chem. 253: 7040–7046. PMID 690139. 
  3. Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). "Purification and characterization of rhodopsin kinase". J. Biol. Chem. 263: 14067–14073. PMID 2844754. 
  4. Weller, M., Virmaux, N. and Mandel, P. (1975). "Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin". Proc. Natl. Acad. Sci. USA 72: 381–385. PMID 164024. 
  5. Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). "Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications". Proc. Natl. Acad. Sci. USA 94: 10577–10582. PMID 9380677. 
  6. Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). "Characterization and chromosomal localization of the gene for human rhodopsin kinase". Genomics 35: 571–576. PMID 8812493. 
  7. Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). "Characterization of human GRK7 as a potential cone opsin kinase". Mol. Vis. 7: 305–313. PMID 11754336. 
  8. Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). "Non-visual GRKs: are we seeing the whole picture?". Trends Pharmacol. Sci. 24: 626–633. PMID 14654303. 

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