Ribonukleaza Z
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| Ribonukleaza Z | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.26.11 | ||||||||
| CAS broj | 98148-84-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ribonukleaza Z (EC 3.1.26.11, 3 tRNaza, tRNK 3 endonukleaza, RNaza Z, 3' tRNaza) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endonukleolitičko razlaganje RNK, uklanjanje ekstra 3' nukleotida sa tRNK prekursora, generisanje 3' krajeva tRNK molekula
Ovaj enzim ne koristi kofaktor.
Reference[uredi | uredi kod]
- ↑ Schiffer, S., Rösch, S. and Marchfelder, A. (2002). „Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes”. EMBO J. 21: 2769-2777. PMID 12032089.
- ↑ Mayer, M., Schiffer, S. and Marchfelder, A. (2000). „tRNA 3′ processing in plants: nuclear and mitochondrial activities differ”. Biochemistry 39: 2096-2105. PMID 10684660.
- ↑ Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. (2001). „The plant tRNA 3′ processing enzyme has a broad substrate spectrum”. Biochemistry 40: 8264-8272. PMID 11444972.
- ↑ Kunzmann, A., Brennicke, A. and Marchfelder, A. (1998). „5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria”. Proc. Natl. Acad. Sci. USA 95: 108-113. PMID 9419337.
- ↑ Mörl, M. and Marchfelder, A. (2001). „The final cut. The importance of tRNA 3′-processing”. EMBO Rep. 2: 17-20. PMID 11252717.
- ↑ Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. (2004). „A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima”. J. Biol. Chem. 279: 15688-15697. PMID 14749326.
- ↑ Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. (2003). „A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease”. Nucleic Acids Res. 31: 2272-2278. PMID 12711671.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.