Ribonukleaza Z

Iz Wikipedije, slobodne enciklopedije
Ribonukleaza Z
Identifikatori
EC broj 3.1.26.11
CAS broj 98148-84-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Ribonukleaza Z (EC 3.1.26.11, 3 tRNaza, tRNK 3 endonukleaza, RNaza Z, 3' tRNaza) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endonukleolitičko razlaganje RNK, uklanjanje ekstra 3' nukleotida sa tRNK prekursora, generisanje 3' krajeva tRNK molekula

Ovaj enzim ne koristi kofaktor.

Reference[uredi - уреди | uredi izvor]

  1. Schiffer, S., Rösch, S. and Marchfelder, A. (2002). "Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes". EMBO J. 21: 2769–2777. PMID 12032089. 
  2. Mayer, M., Schiffer, S. and Marchfelder, A. (2000). "tRNA 3′ processing in plants: nuclear and mitochondrial activities differ". Biochemistry 39: 2096–2105. PMID 10684660. 
  3. Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. (2001). "The plant tRNA 3′ processing enzyme has a broad substrate spectrum". Biochemistry 40: 8264–8272. PMID 11444972. 
  4. Kunzmann, A., Brennicke, A. and Marchfelder, A. (1998). "5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria". Proc. Natl. Acad. Sci. USA 95: 108–113. PMID 9419337. 
  5. Mörl, M. and Marchfelder, A. (2001). "The final cut. The importance of tRNA 3′-processing". EMBO Rep. 2: 17–20. PMID 11252717. 
  6. Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. (2004). "A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima". J. Biol. Chem. 279: 15688–15697. PMID 14749326. 
  7. Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. (2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease". Nucleic Acids Res. 31: 2272–2278. PMID 12711671. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]