Ribonukleaza E
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| Ribonukleaza E | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.26.12 | ||||||||
| CAS broj | 76106-82-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ribonukleaza E (EC 3.1.26.12, endoribonukleaza E, RNaza E, Rne protein) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endonukleolitičko razlaganje jednolančane RNK u A- i U-bogate regione
RNaza E je bakterijska ribonukleaza koja učestvuje u obradi ribozomalne RNK (9S do 5S rRNK), hemijskoj degradaciji ćelijske RNK, razlaganju specifičnih regulatornih, informacionih i strukturnih RNK molekula i kontroli plazmidne DNK replikacije.
Reference[uredi | uredi kod]
- ↑ Feng, Y., Vickers, T.A. and Cohen, S.N. (2002). „The catalytic domain of RNase E shows inherent 3′ to 5′ directionality in cleavage site selection”. Proc. Natl. Acad. Sci. USA 99: 14746-14751. PMID 12417756.
- ↑ Ehretsmann, C.P., Carpousis, A.J. and Krisch, H.M. (1992). „Specificity of Escherichia coli endoribonuclease RNase E: in vivo and in vitro analysis of mutants in a bacteriophage T4 mRNA processing site”. Genes Dev. 6: 149-159. PMID 1730408.
- ↑ Cormack, R.S., Genereaux, J.L. and Mackie, G.A. (1993). „RNase E activity is conferred by a single polypeptide: overexpression, purification, and properties of the ams/rne/hmp1 gene product”. Proc. Natl. Acad. Sci. USA 90: 9006-9010. PMID 8415644.
- ↑ Vanzo, N.F., Li, Y.S., Py, B., Blum, E., Higgins, C.F., Raynal, L.C., Krisch, H.M. and Carpousis, A.J. (1998). „Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome”. Genes Dev. 12: 2770-2781. PMID 9732274.
- ↑ Steege, D.A. (2000). „Emerging features of mRNA decay in bacteria”. RNA 6: 1079-1090. PMID 10943888.
- ↑ Callaghan, A.J., Grossmann, J.G., Redko, Y.U., Ilag, L.L., Moncrieffe, M.C., Symmons, M.F., Robinson, C.V., McDowall, K.J. and Luisi, B.F. (2003). „Quaternary structure and catalytic activity of the Escherichia coli ribonuclease E amino-terminal catalytic domain”. Biochemistry 42: 13848-13855. PMID 14636052.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.