Receptor retinoinske kiseline beta

Receptor retinoinske kiseline, beta
	; PDB slika je bazirana na 1xap.
Dostupne strukture
	1dsz, 1hra, 1xap, 1xdk
Identifikatori
Simboli	RARB; HAP; NR1B2; RRB2
Vanjski ID	OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB Gene
Ontologija gena
Molekularna funkcija	• aktivnost transkripcionog faktora; • aktivnost steroidnog hormon receptora; • aktivnost receptora retinoinske kiseline; • aktivnost receptora; • vezivanje jona cinka; • sekvenca-specifično DNK vezivanje; • vezivanje metalnog jona;
Celularna komponenta	• celularna komponenta; • nukleus;
Biološki proces	• transkripcija; • regulacija transkripcije, DNK-zavisna; • prenos signala;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Receptor retinoinske kiseline beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor encoded by the RARB gene.^[1]

Ovaj gen kodira receptor retinoinske kiseline beta, koji je član tiroid-steroid hormon receptorske super-familije nuklearnih transkripcionih regulatora. Ovaj receptor je lokalizovan u citoplazmi i u sub-nuklearnim kompartmanima. On vezuje retinoinsku kiselinu, biološki aktivnu formu vitamina A čime posreduje ćelijsku signalizaciju embrionske morfogene, ćelijski rast i diferencijaciju. Smatra se da ovaj protein ograničava rast mnogih ćelijskih tipova putem regulacije izražavanja gena. Ovaj gen je prvo identifikovan kod hepatocelularnih karcinoma, kod kojih se on nalazi pored integracionog mesta hepatitis B virusa. Ovaj gen izražava najmanje dve transkriptne varijante; jedan dodatni transkript je bio opisan, ali puna dužina njegovog proteina nije bila određena.^[1]

Interakcije[uredi | uredi kod]

Pokazano je da receptor retinoinske kiseline beta ima interakciju sa nuklearni receptor srodnim 1 proteinom.^[2]

Reference[uredi | uredi kod]

↑ ^1,0 ^1,1 „Entrez Gene: RARB retinoic acid receptor, beta”.
↑ Perlmann, T; Jansson L (Apr 1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. (UNITED STATES) 9 (7): 769–82. ISSN 0890-9369. PMID 7705655.

Literatura[uredi | uredi kod]

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