Izvorni kod stranice Receptor retinoinske kiseline alfa

{{PBB|geneid=5914}}
'''Receptor retinoinske kiseline alfa''' ('''RAR-alfa'''), isto poznat kao '''NR1B1''' (nuklearni receptor potfamilije 1, grupa B, član 1), je [[nuklearni receptor]] kodiran [[gen]]om {{gen|RARA}}.

== Interakcije ==
Pokazano je za receptor retinoinske kiseline gama da može da formnira interakciju sa [[NCOA6]],<ref name=pmid11158331>{{cite journal |last=Lee |first=S K |authorlink= |coauthors=Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W |year= 2001 |month=Feb |title=Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 |journal=Mol. Endocrinol. |volume=15 |issue=2 |pages=241–54 |publisher= |location = United States| issn = 0888-8809| pmid = 11158331 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10567404>{{cite journal |last=Lee |first=S K |authorlink= |coauthors=Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W |year= 1999 |month=Nov |title=A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo |journal=J. Biol. Chem. |volume=274 |issue=48 |pages=34283–93 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10567404 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10823961>{{cite journal |last=Ko |first=L |authorlink= |coauthors=Cardona G R, Chin W W |year= 2000 |month=May |title=Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=11 |pages=6212–7 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10823961 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CLOCK]],<ref name=pmid11439184>{{cite journal |last=McNamara |first=P |authorlink= |coauthors=Seo S B, Rudic R D, Sehgal A, Chakravarti D, FitzGerald G A |year= 2001 |month=Jun |title=Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock |journal=Cell |volume=105 |issue=7 |pages=877–89 |publisher= |location = United States| issn = 0092-8674| pmid = 11439184 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TADA3L]],<ref name=pmid12235159>{{cite journal |last=Zeng |first=Musheng |authorlink= |coauthors=Kumar Ajay, Meng Gaoyuan, Gao Qingshen, Dimri Goberdhan, Wazer David, Band Hamid, Band Vimla |year= 2002 |month=Nov |title=Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator |journal=J. Biol. Chem. |volume=277 |issue=47 |pages=45611–8 |publisher= |location = United States| issn = 0021-9258| pmid = 12235159 |doi = 10.1074/jbc.M208447200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cink prst i BTB domen-sadržavajući protein 16]],<ref name=pmid14521715>{{cite journal |last=Martin |first= |authorlink= |coauthors=Delmotte , Formstecher , Lefebvre |year= 2003 |month=Sep |title=PLZF is a negative regulator of retinoic acid receptor transcriptional activity |journal=Nucl. Recept. |volume=1 |issue=1 |pages=6 |publisher= |location = | issn = | pmid = 14521715 |doi = 10.1186/1478-1336-1-6 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Src (gen)|Src]],<ref name=pmid10454579>{{cite journal |last=Kim |first=H J |authorlink= |coauthors=Yi J Y, Sung H S, Moore D D, Jhun B H, Lee Y C, Lee J W |year= 1999 |month=Sep |title=Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation |journal=Mol. Cell. Biol. |volume=19 |issue=9 |pages=6323–32 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10454579 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1999-09_19_9/page/6323| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12612084>{{cite journal |last=He |first=Bin |authorlink= |coauthors=Wilson Elizabeth M |year= 2003 |month=Mar |title=Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs |journal=Mol. Cell. Biol. |volume=23 |issue=6 |pages=2135–50 |publisher= |location = United States| issn = 0270-7306| pmid = 12612084 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_2003-03_23_6/page/2135| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Nuklearni receptor srodni 1 protein]] (NURR1),<ref name=pmid7705655>{{cite journal |last=Perlmann |first=T |authorlink= |coauthors=Jansson L |year= 1995 |month=Apr |title=A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1 |journal=Genes Dev. |volume=9 |issue=7 |pages=769–82 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 7705655 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Mali heterodimer partner]] (SHP),<ref name=pmid8650544>{{cite journal |last=Seol |first=W |authorlink= |coauthors=Choi H S, Moore D D |year= 1996 |month=May |title=An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors |journal=[[Science (journal)|Science]] |volume=272 |issue=5266 |pages=1336–9 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 8650544 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9773978>{{cite journal |last=Seol |first=W |authorlink= |coauthors=Hanstein B, Brown M, Moore D D |year= 1998 |month=Oct |title=Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner) |journal=Mol. Endocrinol. |volume=12 |issue=10 |pages=1551–7 |publisher= |location = UNITED STATES| issn = 0888-8809| pmid = 9773978 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[NPAS2]],<ref name=pmid11439184/> [[Cyclin D3]],<ref name=pmid12482873>{{cite journal |last=Despouy |first=Gilles |authorlink= |coauthors=Bastie Jean-Nöel, Deshaies Sylvie, Balitrand Nicole, Mazharian Alexandra, Rochette-Egly Cécile, Chomienne Christine, Delva Laurent |year= 2003 |month=Feb |title=Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II |journal=J. Biol. Chem. |volume=278 |issue=8 |pages=6355–62 |publisher= |location = United States| issn = 0021-9258| pmid = 12482873 |doi = 10.1074/jbc.M210697200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Nuklearni receptor korepresor 1]],<ref name=pmid10336495>{{cite journal |last=Dowell |first=P |authorlink= |coauthors=Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M |year= 1999 |month=May |title=Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein |journal=J. Biol. Chem. |volume=274 |issue=22 |pages=15901–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10336495 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9531570>{{cite journal |last=Guidez |first=F |authorlink= |coauthors=Ivins S, Zhu J, Söderström M, Waxman S, Zelent A |year= 1998 |month=Apr |title=Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia |journal=Blood |volume=91 |issue=8 |pages=2634–42 |publisher= |location = UNITED STATES| issn = 0006-4971| pmid = 9531570 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BAG1]],<ref name=pmid9642262>{{cite journal |last=Liu |first=R |authorlink= |coauthors=Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K |year= 1998 |month=Jul |title=Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells |journal=J. Biol. Chem. |volume=273 |issue=27 |pages=16985–92 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9642262 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Nuklearni receptor korepresor 2]],<ref name=pmid11929748>{{cite journal |last=Dong |first=Shuo |authorlink= |coauthors=Tweardy David J |year= 2002 |month=Apr |title=Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways |journal=Blood |volume=99 |issue=8 |pages=2637–46 |publisher= |location = United States| issn = 0006-4971| pmid = 11929748 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9256429>{{cite journal |last=Hong |first=S H |authorlink= |coauthors=David G, Wong C W, Dejean A, Privalsky M L |year= 1997 |month=Aug |title=SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=17 |pages=9028–33 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9256429 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[NRIP1]],<ref name=pmid14581481>{{cite journal |last=Hu |first=Xinli |authorlink= |coauthors=Chen Yixin, Farooqui Mariya, Thomas Mary C, Chiang Cheng-Ming, Wei Li-Na |year= 2004 |month=Jan |title=Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation |journal=J. Biol. Chem. |volume=279 |issue=1 |pages=319–25 |publisher= |location = United States| issn = 0021-9258| pmid = 14581481 |doi = 10.1074/jbc.M307621200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12549917>{{cite journal |last=Farooqui |first=Mariya |authorlink= |coauthors=Franco Peter J, Thompson Jim, Kagechika Hiroyuki, Chandraratna Roshantha A S, Banaszak Len, Wei Li-Na |year= 2003 |month=Feb |title=Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity |journal=Biochemistry |volume=42 |issue=4 |pages=971–9 |publisher= |location = United States| issn = 0006-2960| pmid = 12549917 |doi = 10.1021/bi020497k | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8887632>{{cite journal |last=L'Horset |first=F |authorlink= |coauthors=Dauvois S, Heery D M, Cavaillès V, Parker M G |year= 1996 |month=Nov |title=RIP-140 interacts with multiple nuclear receptors by means of two distinct sites |journal=Mol. Cell. Biol. |volume=16 |issue=11 |pages=6029–36 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 8887632 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1996-11_16_11/page/6029| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Protein promielocitna leukemije]]<ref name=pmid10610177>{{cite journal |last=Zhong |first=S |authorlink= |coauthors=Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman L P, Pandolfi P P |year= 1999 |month=Nov |title=A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins |journal=Nat. Genet. |volume=23 |issue=3 |pages=287–95 |publisher= |location = UNITED STATES| issn = 1061-4036| pmid = 10610177 |doi = 10.1038/15463 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> i [[Retinoidni X receptor alfa]].<ref name=pmid12052862>{{cite journal |last=Benkoussa |first=Madjid |authorlink= |coauthors=Brand Céline, Delmotte Marie-Hélène, Formstecher Pierre, Lefebvre Philippe |year= 2002 |month=Jul |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter |journal=Mol. Cell. Biol. |volume=22 |issue=13 |pages=4522–34 |publisher= |location = United States| issn = 0270-7306| pmid = 12052862 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_2002-07_22_13/page/4522| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid1314167>{{cite journal |last=Bugge |first=T H |authorlink= |coauthors=Pohl J, Lonnoy O, Stunnenberg H G |year= 1992 |month=Apr |title=RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors |journal=EMBO J. |volume=11 |issue=4 |pages=1409–18 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 1314167 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_embo-journal_1992-04_11_4/page/1409| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

== Reference ==
{{reflist|2}}

== Povezano ==
* [[Receptor retinoinske kiseline]]
* [[Akutna promijelocitna leukemija]]
{{-}}
{{PDB Galerija-lat|geneid=5914}}
{{Transkripcioni faktori-lat|g2}}

{{DEFAULTSORT:Receptor retinoinske kiseline alfa}}
[[Kategorija:Intracelularni receptori]]
[[Kategorija:Transkripcioni faktori]]