RRNK mala podjedinica pseudouridinske metiltransferaze Nep1

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rRNK mala podjedinica pseudouridinske metiltransferaze Nep1
Identifikatori
EC broj 2.1.1.260
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

rRNK mala podjedinica pseudouridinske metiltransferaze Nep1 (EC 2.1.1.260, Nep1, nukleolarni esencijalni protein 1) je enzim sa sistematskim imenom S-adenozil-L-metionin:18S rRNK (pseudouridin1191-N1)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + pseudouridin1191 u kvašćanoj 18S rRNK S-adenozil-L-homocistein + N1-metilpseudouridin1191 u kvašćanoj 18S rRNK

Ovaj enzim se javlja kod prokariota i eukariota. On specifično prepoznaje pseudouridinske ostatke (Psi) u malim podjedinicama ribozomalne RNK na bazi lokalne RNK strukture.

Reference[uredi | uredi kod]

  1. Taylor, A.B., Meyer, B., Leal, B.Z., Kötter, P., Schirf, V., Demeler, B., Hart, P.J., Entian, K.-D. and Wöhnert, J. (2008). „The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site”. Nucleic Acids Res. 36: 1542-1554. PMID 18208838. 
  2. Wurm, J.P., Meyer, B., Bahr, U., Held, M., Frolow, O., Kötter, P., Engels, J.W., Heckel, A., Karas, M., Entian, K.-D. and Wöhnert, J. (2010). „The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase”. Nucleic Acids Res. 38: 2387-2398. PMID 20047967. 
  3. Meyer, B., Wurm, J.P., Kötter, P., Leisegang, M.S., Schilling, V., Buchhaupt, M., Held, M., Bahr, U., Karas, M., Heckel, A., Bohnsack, M.T., Wöhnert, J. and Entian, K.-D. (2011). „The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA”. Nucleic Acids Res. 39: 1526-1537. PMID 20972225. 

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