RNK helikaza

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RNK helikaza
8ohm.jpg
Dimer RNK helikaze (virus hepatitisa C)
Identifikatori
EC broj 3.6.4.13
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

RNK helikaza (EC 3.6.4.13, CSFV NS3 helikaza, DBP2, DbpA, DDX17, DDX25, DDX3, DDX3X, DDX3Y, DDX4, DDX5, DEAD-box protein DED1, DEAD-kutija RNK helikaza, DEAH-kutija protein 2, DEAH-kutija RNK helikaza, DED1, Dex(H/D) RNK helikaza, EhDEAD1, EhDEAD1 RNK helikaza, eIF4A helikaza, KOKV helikaza, Mtr4p, nestrukturni protein 3 helikaza, NPH-II, RHA, RNK helikaza A, RNK helikaza DDX3, RNK helikaza Hera, RNK-zavisna ATPaza, TGBp1 NTPaza/helikaza domen, VRH1, GRTH/DDX25) je enzim sa sistematskim imenom ATP fosfohidrolaza (odvijanje RNK heliksa).[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + H2O ADP + fosfat

RNK helikaze koriste energiju ATP hidrolize za odvijanje RNK molekula.

Reference[uredi - уреди | uredi izvor]

  1. Cordin, O., Tanner, N.K., Doere, M., Linder, P. and Banroques, J. (2004). "The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity". EMBO J. 23: 2478–2487. PMID 15201868. 
  2. Rodamilans, B. and Montoya, G. (2007). "Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63: 283–286. PMID 17401195. 
  3. Lee, C.G. and Hurwitz, J. (1992). "A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3′ to 5′ direction". J. Biol. Chem. 267: 4398–4407. PMID 1537828. 
  4. Li, S.C., Chung, M.C. and Chen, C.S. (2001). "Cloning and characterization of a DEAD box RNA helicase from the viable seedlings of aged mung bean". Plant Mol. Biol. 47: 761–770. PMID 11785937. 
  5. Wu, J., Bera, A.K., Kuhn, R.J. and Smith, J.L. (2005). "Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing". J. Virol. 79: 10268–10277. PMID 16051820. 
  6. Gross, C.H. and Shuman, S. (1998). "The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication". J. Virol. 72: 4729–4736. PMID 9573237. 
  7. Frick, D.N. (2007). "The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target". Curr. Issues Mol. Biol. 9: 1–20. PMID 17263143. 
  8. Ivanov, K.A. and Ziebuhr, J. (2004). "Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5′-triphosphatase activities". J. Virol. 78: 7833–7838. PMID 15220459. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]