Prozolanapiron-II oksidaza
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| Prozolanapiron-II oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.3.42 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Prozolanapiron-II oksidaza (EC 1.1.3.42, Sol5, SPS, solanapironska sintaza, prozolanapironska II oksidaza) je enzim sa sistematskim imenom prozolanapiron-II:kiseonik 3'-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- prosolanapiron II + O2 prosolanapiron III +H2O2
Ovaj enzim učestvuje u biosintezi fitotoksina solanapirona u nekim gljivama. On je bifunkcionalani enzim koji katalizuje oksidaciju prozolanapirona II i naknadnu Diels Alderovu cikloizomerizaciju produkta prozolanapirona III do (-)-solanapirona A (cf. EC 5.5.1.20, prozolanapiron III cikloizomeraza).
Reference[uredi | uredi kod]
- ↑ Kasahara, K., Miyamoto, T., Fujimoto, T., Oguri, H., Tokiwano, T., Oikawa, H., Ebizuka, Y. and Fujii, I. (2010). „Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani”. Chembiochem. 11: 1245-1252. PMID 20486243.
- ↑ Katayama, K., Kobayashi, T., Oikawa, H., Honma, M. and Ichihara, A. (1998). „Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction”. Biochim. Biophys. Acta 1384: 387-395. PMID 9659400.
- ↑ Katayama, K., Kobayashi, T., Chijimatsu, M., Ichihara, A. and Oikawa, H. (2008). „Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani”. Biosci. Biotechnol. Biochem. 72: 604-607. PMID 18256508.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.