Protein farneziltransferaza

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Protein farneziltransferaza
Identifikatori
EC broj 2.5.1.58
CAS broj 131384-38-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Protein farneziltransferaza (EC 2.5.1.58, FTaze) je enzim sa sistematskim imenom farnezil-difosfat:protein-cistein farneziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

farnezil difosfat + protein-cistein S-farnezil protein + difosfat

Ovaj enzim, zajedno sa proteinskom geranilgeraniltransferazom tip I (EC 2.5.1.59) i II (EC 2.5.1.60) sačinjava proteinsku preniltransferaznu familiju enzima.

Reference[uredi - уреди | uredi izvor]

  1. Furfine, E.S., Leban, J.J., Landavazo, A., Moomaw, J.F. and Casey, P.J. (1995). "Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release". Biochemistry 34: 6857–6862. PMID 7756316. 
  2. Casey, P.J. and Seabra, M.C. (1996). "Protein prenyltransferases". J. Biol. Chem. 271: 5289–5292. PMID 8621375. 
  3. Long, S.B., Casey, P.J. and Beese, L.S. (1998). "Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate". Biochemistry 37: 9612–9618. PMID 9657673. 
  4. Micali, E., Chehade, K.A., Isaacs, R.J., Andres, D.A. and Spielmann, H.P. (2001). "Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups". Biochemistry 40: 12254–12265. PMID 11591144. 
  5. Long, S.B., Casey, P.J. and Beese, L.S. (2002). "Reaction path of protein farnesyltransferase at atomic resolution". Nature 419: 645–650. PMID 12374986. 
  6. Gibbs, R.A. (1998). "Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis". u: Sinnott, M.. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. str. 31-118. 

Literatura[uredi - уреди | uredi izvor]

  • Gibbs, R.A. (1998). "Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis". u: Sinnott, M.. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. str. 31-118. 

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