Protein O-GlcNAc transferaza
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| Protein O-GlcNAc transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.255 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Protein O-GlcNAc transferaza (EC 2.4.1.255, O-GlcNAc transferaza, OGTase, O-vezana N-acetilglukozaminiltransferaza, uridin difosfo-N-acetilglukozamin:polipeptid beta-N-acetilglukozaminiltransferaza, protein O-vezani beta-N-acetilglukozamin transferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:protein-O-beta-N-acetil-D-glukozaminil transferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) UDP-N-acetil-D-glukozamin + [protein]-L-serin UDP + [protein]-3-O-(N-acetil-D-glukozaminil)-L-serin
- (2) UDP-N-acetil-D-glukozamin + [protein]-L-treonin UDP + [protein]-3-O-(N-acetil-D-glukozaminil)-L-treonin
Kod viših eukariota posttranslaciona modifikacija proteinskih serina/treonina N-acetilglukozaminom (O-GlcNAc) je dinamička, induktivna i obilna.
Reference[uredi | uredi kod]
- ↑ Banerjee, S., Robbins, P.W. and Samuelson, J. (2009). „Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum”. Glycobiology 19: 331-336. PMID 18948359.
- ↑ Clarke, A.J., Hurtado-Guerrero, R., Pathak, S., Schuttelkopf, A.W., Borodkin, V., Shepherd, S.M., Ibrahim, A.F. and van Aalten, D.M. (2008). „Structural insights into mechanism and specificity of O-GlcNAc transferase”. EMBO J. 27: 2780-2788. PMID 18818698.
- ↑ Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M. and van Aalten, D.M. (2006). „Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis”. EMBO J. 25: 1569-1578. PMID 16541109.
- ↑ Haltiwanger, R.S., Blomberg, M.A. and Hart, G.W. (1992). „Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase”. J. Biol. Chem. 267: 9005-9013. PMID 1533623.
- ↑ Lubas, W.A., Frank, D.W., Krause, M. and Hanover, J.A. (1997). „O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats”. J. Biol. Chem. 272: 9316-9324. PMID 9083068.
- ↑ Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P. and Walker, S. (2011). „Structure of human O-GlcNAc transferase and its complex with a peptide substrate”. Nature 469: 564-567. PMID 21240259.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.