Prostamid/prostaglandin F2alfa sintaza
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| Prostamid/prostaglandin F2alfa sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.1.20 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Prostamid/prostaglandin F2alfa sintaza (EC 1.11.1.20, prostamid/PGF sintaza, prostamidna F sintaza, prostamid/prostaglandinska F sintaza, tPGF sintaza) je enzim sa sistematskim imenom tioredoksin:(5Z,9alfa,11alfa,13E,15S)-9,11-epidioksi-15-hidroksi-prosta-5,13-dienoat oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tioredoksin + (5Z,9alfa,11alfa,13E,15S)-9,11-epidioksi-15-hidroksi-prosta-5,13-dienoat tioredoksin disulfid + (5Z,9alfa,11alfa,13E,15S)-9,11,15-trihidroksiprosta-5,13-dienoat
Ovaj enzim sadrži tioredoksinski tip disulfida kao katalitičku grupu. Prostamid H2 i prostaglandin H2 su najbolji supstrati.
Reference[uredi | uredi kod]
- ↑ Moriuchi, H., Koda, N., Okuda-Ashitaka, E., Daiyasu, H., Ogasawara, K., Toh, H., Ito, S., Woodward, D.F. and Watanabe, K. (2008). „Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily”. J. Biol. Chem. 283: 792-801. PMID 18006499.
- ↑ Yoshikawa, K., Takei, S., Hasegawa-Ishii, S., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., Woodward, D.F., Watanabe, K. and Shimada, A. (2011). „Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system”. Brain Res. 1367: 22-32. PMID 20950588.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.