Prostaglandin-E sintaza
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| Prostaglandin-E sintaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 5.3.99.3 | ||||||||
| CAS broj | 52227-79-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Prostaglandin-E sintaza (EC 5.3.99.3, prostaglandin-H2 E-izomeraza, endoperoksidna izomeraza, endoperoksidna izomeraza, prostaglandin R-prostaglandinska E izomeraza, prostaglandin endoperoksidna E izomeraza, PGE izomeraza, PGH-PGE izomeraza, PGE2 izomeraza, prostaglandin endoperoksid E2 izomeraza, prostaglandin H-E izomeraza) je enzim sa sistematskim imenom (5Z,13E)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat E-izomeraza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5Z,13E)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat (5Z,13E)-(15S)-11alfa,15-dihidroksi-9-oksoprosta-5,13-dienoat
Ovaj enzim uzrokuje otvaranje epidioksilnog mosta.
Reference[uredi | uredi kod]
- ↑ Ogino, N., Miyamoto, T., Yamamoto, S. and Hayaishi, O. (1977). „Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme”. J. Biol. Chem. 252: 890-895. PMID 838703.
- ↑ Tanaka, Y., Ward, S.L. and Smith, W.L. (1987). „Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes”. J. Biol. Chem. 262: 1374-1381. PMID 3100531.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.