Proproteinska konvertaza 2
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| Proproteinska konvertaza, subtilisin/keksin tip 2 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | PCSK2; NEC2; PC2; SPC2 | ||
| Vanjski ID | OMIM: 162151 MGI: 97512 HomoloGene: 37640 GeneCards: PCSK2 Gene | ||
| EC broj | 3.4.21.94 | ||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 5126 | 18549 | |
| Ensembl | ENSG00000125851 | ENSMUSG00000027419 | |
| UniProt | P16519 | P21661 | |
| RefSeq (mRNA) | NM_002594 | NM_008792 | |
| RefSeq (protein) | NP_002585 | NP_032818 | |
| Lokacija (UCSC) | Chr 20: 17.15 - 17.41 Mb | Chr 2: 143.37 - 143.64 Mb | |
| PubMed pretraga | [1] | [2] | |
| Proproteinska konvertaza 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.94 | ||||||||
| CAS broj | 130960-94-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Ontologija gena | AmiGO / EGO | ||||||||
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Proproteinska konvertaza 2 (PC2), (prohormonska konvertaza 2, neuroendokrinska konvertaza 2 (NEC2)) je serinska proteaza i proproteinska konvertaza PC2. Poput proproteinske konvertaze 1 (PC1), to je enzim odgovoran za prvi korak u maturaciji mnogih neuroendokrinih peptida iz njihovih prekursora, kao što je konverzija proinsulina u insulinske međuprodukte. Da bi se generisala bioaktivna forma insulina (i mnogih drugih peptida), sekundarni korak koji se sastoji od uklanjanja C-terminalnih baznih ostataka je neophodan. Taj korak je posredovan karboksipeptidazama E i/ili D. PC2 ima samo manju ulogu u prvom koraku biosinteze insulina, dok je njegova uloga značajnija u prvom stepenu biosinteze glukagona u poređenju sa PC1. PC2 se vezuje za neuroendokrini protein 7B2, i ako taj protein nije prisutan, proPC2 ne može da postane enzimatski aktivan. 7B2 takođe inhibira PC2 dejstvo dok se 7B2 ne ispreseca u manje neaktivne forme. Stoga je 7B2 aktivator i inhibitor PC2 enzima.
Kod čoveka, proproteinska konvertaza 2 je kodirana PCSK2 genom.[1] On je srodan sa bakterijskim enzimom subtilisinom. Sve zajedno postoji devet različitih subtilisinu-sličnih gena kod sisara: furin, PACE4, PC4, PC5/6, PC7/8, PCSK9 i SKI1/S1P.
Literatura[uredi | uredi kod]
- ↑ Seidah NG, Mattei MG, Gaspar L, Benjannet S, Mbikay M, Chrétien M (September 1991). „Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)”. Genomics 11 (1): 103–7. DOI:10.1016/0888-7543(91)90106-O. PMID 1765368.
Dodatna literatura[uredi | uredi kod]
- Leak TS, Keene KL, Langefeld CD, et al. (2007). „Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population.”. Mol. Genet. Metab. 92 (1-2): 145–50. DOI:10.1016/j.ymgme.2007.05.014. PMC 2752824. PMID 17618154.
- Oguri M, Kato K, Yokoi K, et al. (2010). „Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.”. Am. J. Hypertens. 23 (1): 70–7. DOI:10.1038/ajh.2009.190. PMID 19851296.
- Zemunik T, Boban M, Lauc G, et al. (2009). „Genome-wide association study of biochemical traits in Korcula Island, Croatia.”. Croat. Med. J. 50 (1): 23–33. DOI:10.3325/cmj.2009.50.23. PMC 2657564. PMID 19260141.
- Shen X, Li QL, Brent GA, Friedman TC (2005). „Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter.”. Am. J. Physiol. Endocrinol. Metab. 288 (1): E236–45. DOI:10.1152/ajpendo.00144.2004. PMID 15585599.
- Rehfeld JF, Bundgaard JR, Hannibal J, et al. (2008). „The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.”. Endocrinology 149 (4): 1600–8. DOI:10.1210/en.2007-0278. PMC 2734493. PMID 18096669.
- Deloukas P, Matthews LH, Ashurst J, et al. (2001). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
- Mbikay M, Seidah NG, Chrétien M (2001). „Neuroendocrine secretory protein 7B2: structure, expression and functions.”. Biochem. J. 357 (Pt 2): 329–42. DOI:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.
- Fuller JA, Brun-Zinkernagel AM, Clark AF, Wordinger RJ (2009). „Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.”. Invest. Ophthalmol. Vis. Sci. 50 (12): 5759–68. DOI:10.1167/iovs.08-2616. PMID 19339735.
- Winsky-Sommerer R, Grouselle D, Rougeot C, et al. (2003). „The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease.”. Neuroscience 122 (2): 437–47. DOI:10.1016/S0306-4522(03)00560-8. PMID 14614908.
- Wang J, Xu J, Finnerty J, et al. (2001). „The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.”. Diabetes 50 (3): 534–9. DOI:10.2337/diabetes.50.3.534. PMID 11246872.
- Tzimas GN, Chevet E, Jenna S, et al. (2005). „Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.”. BMC Cancer 5: 149. DOI:10.1186/1471-2407-5-149. PMC 1310616. PMID 16293189.
- Deftos LJ, Burton D, Hastings RH, et al. (2001). „Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues.”. Endocrine 15 (2): 217–24. DOI:10.1385/ENDO:15:2:217. PMID 11720250.
- Ohagi S, Yoshida H, Nanjo K (1994). „[Analysis of the gene encoding human PC2, a prohormone processing enzyme]”. Nippon Rinsho 52 (10): 2544–9. PMID 7983775.
- Li QL, Jansen E, Brent GA, et al. (2000). „Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor.”. Endocrinology 141 (9): 3256–66. DOI:10.1210/en.141.9.3256. PMID 10965896.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yoshida T, Kato K, Yokoi K, et al. (2009). „Association of gene polymorphisms with chronic kidney disease in Japanese individuals.”. Int. J. Mol. Med. 24 (4): 539–47. PMID 19724895.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). „The proprotein convertases furin and PACE4 play a significant role in tumor progression.”. Mol. Carcinog. 28 (2): 63–9. DOI:10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C. PMID 10900462.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Takahashi T, Ida T, Sato T, et al. (2009). „Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.”. J. Biochem. 146 (5): 675–82. DOI:10.1093/jb/mvp112. PMID 19628676.
- {{cite journal |author=Zhu X, Lindberg I |title=7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. |journal=J Cell Biol. |volume=129 |issue= 6 |pages= 1641–50 |year= 1995 |pmid= 7790360| pmc=2291188|