Proproteinska konvertaza 1
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| Proproteinska konvertaza 1 | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.4.21.93 | ||||||||
| CAS broj | 99676-46-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Proproteinska konvertaza 1 (EC 3.4.21.93, prohormonska konvertaza 3, neuroendokrina konvertaza 1, PC1) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Izdvajanje proteinskih hormona, neuropeptida i renina iz njihovih prekursora, generalno putem hidrolize -Lys-Arg- veza
Oaj enzim je zavistan od Ca2+, i maksimalno je aktivan na pH 5.5.
Reference[uredi | uredi kod]
- ↑ Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M. and Chrétien, M. (1990). „cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases”. DNA Cell Biol. 9: 415-424. PMID 2169760.
- ↑ Smeekens, S.P., Avruch, A.S., LaMendola, J., Chan, S.J. and Steiner, D.F. (1991). „Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans”. Proc. Natl. Acad. Sci. USA 88: 340-344. PMID 1988934.
- ↑ Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J. (1992). „The new enzymology of precursor processing endoproteases”. J. Biol. Chem. 267: 23435-23438. PMID 1429684.
- ↑ Seidah, N.G. and Chrétien, M. (1994). „Pro-protein convertases of the subtilisin/kexin family”. Methods Enzymol. 244: 175-188. PMID 7845206.
- ↑ Jean, F., Basak, A., Dimaio, J., Seidah, N.G. and Lazure, C. (1995). „An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor”. Biochem. J. 307: 689-695. PMID 7741698.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.