Propionil-KoA C2-trimetiltridekanoiltransferaza
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| Propionil-KoA C2-trimetiltridekanoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.154 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Propionil-KoA C2-trimetiltridekanoiltransferaza (EC 2.3.1.154, 3-oksopristanoil-KoA hidrolaza, 3-oksopristanoil-KoA tiolaza, peroksizom sterolni nosilac protein tiolaza, sterolni nosilac protein, oksopristanoil-KoA tiolaza, peroksizomalna 3-oksoacil koenzim A tiolaza, SCPx, 4,8,12-trimetiltridekanoil-KoA:propanoil-KoA 2-C-4,8,12-trimetiltridekanoiltransferaza) je enzim sa sistematskim imenom 4,8,12-trimetiltridekanoil-KoA:propanoil-KoA C2-4,8,12-trimetiltridekanoiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4,8,12-trimetiltridekanoil-KoA + propanoil-KoA KoA + 3-oksopristanoil-KoA
Peroksizomal protein sterolni nosilac protein X (SCPx) kombinuje ovu tiolaznu aktivnost sa funkcijom nosiloca. On učestvuje u beta oksidaciji razgranatih masnih kiselina u peroksizomima.
Reference[uredi | uredi kod]
- ↑ Seedorf, U., Brysch, P., Engel, T., Schrage, K. and Assmann, G. (1994). „Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity”. J. Biol. Chem. 269: 21277-21283. PMID 8063752.
- ↑ Wanders, R.J.A., Denis, S., Wouters, F., Wirtz, K.W.A. and Seedorf, U. (1997). „Sterol carrier protein X (SCPx) is a peroxisomal branched-chain β-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes”. Biochem. Biophys. Res. Commun. 236: 565-569. PMID 9245689.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.