Prokolagenska N-endopeptidaza
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| Prokolagenska N-endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.14 | ||||||||
| CAS broj | 68651-94-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prokolagenska N-endopeptidaza (EC 3.4.24.14, prokolagen N-terminalna peptidaza, prokolagenska aminopeptidaza, aminoprokolagenska peptidaza, aminoterminalna prokolagenska peptidaza, prokolagenska aminoterminalna proteaza, prokolagenska N-terminalna proteinaza, tip I/II prokolagenska N-proteinaza, tip III prokolagen) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje N-propeptidnog lanca kolagena alfa1(I) na Pro-Gln, kao i alfa1(II) i alfa2(I) na Ala-Gln
Ovaj enzim deluje na propeptide tipa I i II kolagena.
Reference[uredi | uredi kod]
- ↑ Kohn, L.D., Iserky, C., Zupnik, J., Lenaers, A., Lee, G. and Lapiére, C.M. (1974). „Calf tendon procollagen peptidase: its purification and endopeptidase mode of action”. Proc. Natl. Acad. Sci. USA 71: 40-44. PMID 4204204.
- ↑ Hojima, Y., McKenzie, J., van der Rest, M. and Prockop, D.J. (1989). „Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides”. J. Biol. Chem. 264: 11336-11345. PMID 2500439.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.